Nature: SINAT5 promotes ubiquitin related degradation of NAC1 to attenuate auxin signals
Nature Cell Biology: Astral microtubules monitor metaphase spindle alignment in fission yeast
TLL files a patent for Nucleic Acids from Rice Conferring Resistance to Bacterial Blight Disease Casued by Xanthomonas spp (PCT/SG2003/000191)
Current Opinion in Cell Biology: Cytokinesis: relative alignment of the cell division apparatus and the mitotic spindle
Trends in Genetics: Cytokinesis in fission yeast: a story of rings, rafts and walls
TLL and the Institute of Genetics Developmental Biology of Chinese Academy of Science forms joint laboratory on rice functional genomics
Genes and Development: Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes
Developmental Cell: The S. pombe Cdc14-like Phosphatase Clp1p Regulates Chromosome Biorientation and Interacts with Aurora Kinase
TLL discovers the molecular interaction between a resistance gene in rice and pathogenic bacteria, and its effect on disease resistance in rice
TLL conducts regional biosafety training with the Canadian International Development Agency (CIDA) and Singapore Ministry of Foreign Affairs (MFA)
Nature: R gene expression induced by a type-III effector triggers disease resistance in rice
Science: The Transcriptional Landscape of the Mammalian Genome
Cell: Have you HRD? Understanding ERAD Is DOAble!
(read more)
Genes & Development: Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
(read more)
TLL and the Institute of Botany of Chinese Academy of Science forms joint laboratory on bioenergy crops
Nature: Two distinct modes of guidance signaling during collective migration of border cells
Nature: Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
Wang Hongyan receives Singapore National Young Scientist Medal & National Research Foundation Fellow
TLL files a patent for Monoclonal antibodies specific to hemagglutinin and Neuraminidase from Influenza virus H5-subtype or N1-subtype and Uses thereof (PCT/SG2008/000347)
Nature Cell Biology: Lectins sweet-talk proteins into ERAD
Nature: Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage
Regeneration and Mass Propagation of Jatropha curcas Through Somatic Embryogenesis (PCT/SG2009/000015)
Genes and Development: Protein Phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions
Nature Neuroscience: A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning
Developmental Cell: Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal
Developmental Cell: DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs
TLL and AVA receives Grant Award from National Research Foundation on Applied Aquaculture Genomics R&D
TLL receives additional grants from National Research Foundation on Rice Research for Regional Food Security
Molecular Cell: A Complex of Pdi1p and the Mannosidase Htm1p Initiates Clearance of Unfolded Glycoproteins from the Endoplasmic Reticulum
Neuron: Intrinsic Epigenetic Factors Cooperate with the Steroid Hormone Ecdysone to Govern Dendrite Pruning in Drosophila
TLL develops plant and microbial systems for flavours and fragrances with National Research Foundation
TLL sponsors Outstanding Poster Abstract Entries at the ‘Next Generation Technologies for Bioenergy and Biomass Utilization’ International Conference
Cell: Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Small RNA
Molecular Cell: The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network
TLL and Temasek Foundation customises rice cultivation programmes with the Indonesian Agency for Agricultural R&D
TLL young scientists Dr Zhang Dan and Dr Dr Guillaume Thibault received Chinese Government Award and Elite Nanyang Assistant Professorship Award for academic excellence
Nitrogen-fixing Bacterial Inoculant for Improvement of Crop Productivity and Reduction of Nitrous Oxide Emission (PCT/SG2013/000112)
Nature Cell Biology: In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics
Science: Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
TLL spins off Allegro Aqua
TLL commences research on Disruptive, Sustainable Technologies for Agricultural Precision (DiSTAP)
Nature Chemical Biology: Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit
Nature Communications: Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy
TLL spins off Zero 2.5 (video)
Temasek Rice ready to take on global market after grant of plant varieties protection (video)
TLL files patents for Apparatus and Device for Generating Negative Air Ions from Plants (PCT/SG2019/050130) and Application of A Food Azo Dye, Brilliant Black Bn, on Inhibition of Infectivity of Human Enteroviruses Causing Hand Foot And Mouth Diseases (PCT/SG2019/050130)
Nature Nanotechnology: Chloroplast-selective gene delivery and expression in planta using chitosan-complexed single-walled carbon nanotube carriers
Nucleic Acids Research: Hidden sequence specificity in loading of single-stranded RNAs onto Drosophila Argonautes
Covid-19 Pandemic: TLL joins Temasek Foundation in testing water and hand sanitiser quality, as well as public distribution for BYOB Hand Sanitiser Project
(video)
Louis Dreyfus Company Partners Barramundi Asia and TLL on Aqua Feed Research (video)
Advanced Science: Mesostigma viride Genome and Transcriptome Provide Insights into the Origin and Evolution of Streptophyta
Molecular Cell: Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
Covid 19 Pandemic: TLL joins Temasek Foundation in testing non alcoholic hand sanitisers for BYOB Hand Sanitiser Project (video)
TLL spins off Aqualita Ecotechnology (video)
Science: Florigen sequestration in cellular membranes modulates temperature-responsive flowering
Molecular Biology and Evolution: Genomic Basis of Striking Fin Shapes and Colors in the Fighting Fish
TLL hosts Singapore Ministers for Sustainability and the Environment, Social and Family Development, and Health
SFA, NUS, TLL and Industry Partners sign MoU for the AquaPolis programme (video)
Nature Microbiology: Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity
A VASt-domain protein regulates autophagy, membrane tension, and sterol homeostasis in rice blast fungus (Autophagy)
Pathnova starts clinical trial on Singaporeans for cancer research
Molecular Plant: G protein controls stress readiness by modulating transcriptional and metabolic homeostasis in Arabidopsis thaliana and Marchantia polymorpha.
Nature: Topological defects in epithelia govern cell death and extrusion
Nature: Embryonic epigenetic reprogramming by a pioneer transcription factor in plants
TLL and Temasek Foundation build capacities in laboratory bio risk management in Laos, Cambodia, Myanmar, Indonesia and Vietnam
Nature Materials: Epithelial bridges maintain tissue integrity during collective cell migration
Cell: The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis
Molecular Cell: Adaptive Regulation of Testis Gene Expression and Control of Male Fertility by the Drosophila Harpin RNA Pathway
Molecular Cell: Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing
TLL launches Training in Biosafety and Infectious Substances Shipping for Public Health Laboratories in Asia Pacific
Singapore’s Temasek Rice Developed by TLL Scientists for Regional Food Security (video)
Singapore led Consortium Deciphers the Genome of Asian Seabass: First Major Tropical Food Fish with its ‘Genetic Blueprint’ Assembled and Read
Genes & Development: JMJ24 targets CHROMOMETHYLASE3 for proteasomal degradation in Arabidopsis
Nature Communications: Pin1At regulates PIN1 polar localization and root
At TLL, our staff and scientists are committed to putting the magic and potency of science to good use. Our first founding decade saw TLL making discoveries, going beyond the ordinary to deepen our collective understanding of the environment and impacting various facets of human life. With vivid dreams conjuring special things….